NSAIDs and Infertility

I posted this on my family blog over 2 years ago and have had several emails lately from people who came across the information and had no idea. I think it warrants a re-post on this new blog and I hope it finds the people who need it most. For natural alternatives to NSAIDs read more about WHAT I USE INSTEAD.


My public service announcement is about the little-known issue of NSAIDS and infertility. NSAIDS when taken on a regular basis can inhibit ovulation BUT it’s more than that. All tests will appear normal. Hormones will still fluctuate, rise, fall etc as they are supposed to. Fertility charts will look good and indicate ovulation. The follicle, however is unruptured. Meaning no little egg actually goes anywhere. And that’s not all (insert tv infomercial voice)…if it DOES go somewhere by chance, the NSAIDS may even contribute to failed implantation.

How many women know this? How many doctors know this? I can tell you that in the past 6 months, I have listed my medications on 5 different doctor’s information sheets(rheumetologist, OBGYN, GI doc, sleep doc and Naturopath) and told all FIVE that I was trying to conceive and NONE commented on the 2X daily prescription NSAID I was taking. Most likely none of them knew anything about it. Which is why I will be sending them copies of these studies.

CLin-Alert – Google Books
1996!!! Rheumatology Journal

I’m thinking this is a serious enough side effect that ALL NSAIDs should have this warning ON THE LABEL (which was NOT on anything I received with the prescription):

(found on Drugs.com)

Impaired female fertility:

The use of Diclofenac Potassium tablets may impair female fertility and is not recommended in women attempting to conceive. In women who may have difficulties conceiving or who are undergoing investigation of infertility, withdrawal of Diclofenac Potassium tablets should be considered.

So, now here’s my personal case study. After 4+ weeks off of Diclofenac, I have positive pregnancy tests. Plural. Lots of them. Because of my previous failed implantations (aka chemical pregnancy) I tested for 8 days straight. No disappearing lines. I am definitely pregnant. ONE CYCLE OFF OF THIS STUFF. Coincidence? No way. ¬†(Update 2013 – Sadly, this pregnancy ended at 12 weeks. Another pregnancy was confirmed 6 weeks later and was also lost at almost 12 weeks.)

So, I am putting this out there for anyone who may not know: If you are trying to conceive…lay off the NSAIDs. Including creams, patches, pills, syrups. ¬†There are alternatives for pain and inflammation and they work well for me!! READ ABOUT NATURAL NSAID ALTERNATIVES HERE. And…in the spirit of helping people through social media….share! You never know who you will help by passing along this information!

This post is also linked at Holistic Squid & Thank Your Body, Wellness Wednesday, Simple Lives Thursday

9 Thoughts on “NSAIDs and Infertility

  1. Aprila, I know this is an “old” new post, but I just wanted to say that I’m sorry for your losses. I’m also incredibly grateful that you shared this info – I had NO IDEA!

  2. admin on March 26, 2013 at 8:16 pm said:

    Thanks, Heather. I learned a lot about life and about myself during that time. Thank you so much for sharing this information. I am always surprised when I find out how few people know about this. Even a couple years later.

  3. Maleahbliss on March 26, 2013 at 9:43 pm said:

    I’m so sorry for your losses, I too have suffered 2 miscarriages. After my second I learned of a study that was testing the effectiveness of low dose aspirin on pregnancies after miscarriage. (The EaGer Study) instead of doing the study, I just took the low dose aspirin daily. I successfully conceived (which I wasn’t having too much trouble doing, but it usually took 6ish months) and carried my baby to term. Plus, it only took 2 months to conceive. When we stared trying for baby #2, I started taking the aspirin immediately, conceived on the first try and again carried her full term with out any problems. In both pregnancies I continued taking the aspirin until about 2 weeks. I attribute the aspirin to my successful pregnancies. I have a friend that this also helped. So, maybe not all NSAIDs are a problem? I’m just speaking from my experience, I don’t think the study has been completed yet.

  4. I had heard about the low-dose aspirin trials and did a round myself. I think there is something to that for people who tend to clot and cut off blood supply on implantation. I’ll be interested in reading the study results!

    The studies I linked in my post focus on higher dose, chronic use of NSAIDs. For me, it was 75mg of Diclofenac twice daily for YEARS.

  5. Thanks for posting (and reposting) this information. I had seven plus years of infertility back in the 1980s and one confirmed and one possible miscarriage. I started taking Ibuprofen in the late 1970s as a prescription medication and then later as an over the counter. Wow, I’m now wondering about it’s role in my fertility issues. I have two daughters in their early twenties and I will be passing this on to them and to my nieces in their childbearing years!

    (Found you from Simple Lives Thursday Blog Hop!)

  6. Thank you, thank you for sharing this with us on Wellness Wednesdays! I had NO idea this contributed to infertility. I haven’t had problems with this, but know some ladies who have. I will be sharing with my readers on facebook and twitter as well as pinning this post. This is very important info.

  7. Pingback: Natural NSAID Substitutes | The Reluctant Healthwife

  8. Tara on July 4, 2013 at 1:23 pm said:

    I too had a miscarriage while taking an NSAID, Voltaren, amongst other rx drugs, (I have RA). We had been going to a fertility doctor for almost 2 years and not once did anyone ever tell us that it might be the reason why we weren’t getting pregnant. Stopped taking the nsaid and boom, a few months later we were pregnant! Thanks for sharing your story.

  9. Pingback: NSAIDS and Infertility | The Natural Fertility Formula

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